Kardashian West posted video on Instagram showing a portion of the blaze. She said she landed back home, spent one hour packing and evacuated shortly afterward.
The fire had grown to more than 14,000 acres and jumped the 101 Freeway in Agoura despite firefighters' best efforts Friday morning, KTLA reported.
"I'm anxious about my house, but there is nothing I can do", she tweeted. "I can't bear the thought of there being no Malibu I've had a house in Malibu since 1972".
Because the central town of Sweetwater is filmed at Melody Ranch, locations such as the train platform and the Mariposa Saloon have not been affected.
The set in the mountains west of Los Angeles dates to 1927 when Paramount Pictures leased the ranch and began making films there.
The site has been home to multiple producations since the 1950s, when its Western Town was created for TV shows, such as "The Cisco Kid:".
The ranch served as a location for productions ranging from 1938′s "The Adventures of Marco Polo" to TV shows "The Mentalist" and "Weeds". According to the Malibu Times, they'd initially planned to use it as a dude ranch, but instead placed ads in the trades and changed tack when studios expressed interest in using it as a filming location.
HBO added in a statement to ET: "Paramount Ranch was one of the locations used during seasons one and two of "Westworld", in addition to the primary location at Melody Ranch in Santa Clarita". Most importantly, our thoughts go out to all of those affected by these disgusting fires'.
California is now experiencing a rash of wildfires, with people being forced to evacuate their homes in the northern part of the state and a separate fire impacting those closer to Hollywood, as well. The blaze also threatens the communities of Calabasas and Woodland Hills.