The airstrikes left at least one Palestinian dead, according to Gaza's Health Ministry.
Palestinian men use slingshots to throw stones at Israeli forces during a demonstration near the border with Israel, east of Gaza City, on October 19, 2018.
The decision was taken after Israeli Prime Minister Benjamin Netanyahu convened his cabinet meeting earlier Wednesday and pledged to take "very strong action" if Palestinian "attacks" continued.
Palestinians have been protesting along the border since March 30, demanding an end to Israel's blockade of the territory and the right to return to lands that Palestinians fled or were driven from upon Israel's founding in 1948.
In addition, 69 of those injured, 14 of whom were children, suffered permanent disability, according to the latest statistics by the Palestinian Ministry of Health in Gaza. Israel has demanded an end to the weekly confrontations, as well as the frequent launches of incendiary balloons into Israeli territory.
More than 2 million Palestinians are packed into the coastal enclave.
"The government's return to Gaza and the lifting of the suffocating movement and access restrictions are necessary for addressing the humanitarian and economic needs of the population in a sustainable manner", he noted, referring to Israel's control over border crossings with Gaza.
Following the targeting of the southern Israeli city on Wednesday, Lieberman ordered the closure of two Gaza border checkpoints and enforcement of a stricter three-nautical-mile limit for Palestinian fishing boats.
The Hamas-led committee organizing the riots released a video marking the 30th week since the "March of Return" campaign was launched with the slogan: "Together Gaza rises up and the West Bank unites."The video calls the Palestinians to attend Friday's riots in droves".
Khalil al-Haya, a top Hamas official, said the Egyptians had discussed cease-fire efforts, as well as on-and-off attempts at reconciliation with the rival Palestinian Authority.
In Gaza, a Palestinian official told Reuters that resistance groups were not seeking war with Israel.
Euro-Med stressed "Israel's response to protests violates the principles of global human rights law; that is, despite the fact that protests have largely been peaceful, Israeli soldiers killed 205 people, including five women and 38 children, while also injuring 22,527 others, 18% of whom are children". The protests have intensified in recent weeks as Egyptian and United Nations cease-fire negotiations have faltered, and cross-border violence earlier this week has brought tensions to a simmer.