The singer explained that he realised he had become too caught up in his own success and he can now no longer stomach "the celebrity narcissism".
He said that he and Luisana - who have two younger children - Elias, two, and 11-week-old Vida - were "very optimistic" about his future.
Michael told the Daily Mail his upcoming album, "Love", may be the last one he ever records. My wife was the same, and even though I was the stronger of the two of us, I wasn't strong.
In a recent interview with The Daily Mail, the Canadian-Italian singer, songwriter, producer, actor, and infinite hunk has revealed that his forthcoming 10th studio record, ❤️, will be his last and for good reason.
Speaking about the process, he said: "It wasn't as straightforward as, 'My son's recovered, I should make an album.' I'd told my manager I wanted to take a ten-year sabbatical, so I could hang out and be bad".
He added: "It's been such a hard exercise. I've made the ideal record and now I can leave at the very top", Buble said. 'I don't know if I can even get through this conversation without crying.
The Just Haven't Met You Yet hitmaker returned to the spotlight once his little boy Noah's condition had improved, but insisted that the devastating impact Noah's diagnosis had on his family has meant he will never put his career before his loved ones.
Though the release of his latest album is set for Novemeber, the singer confessed that his "perception of life" has been changed since dealing with his son's cancer battle and he's now "embarrassed by [his] ego".
Buble also said that helping his son through his illness has given him a new outlook on life and made him realize what's important to him. "And I've never lost control of my emotions in public".
"I actually thought I'd never come back to the music business", Bublé continued.
"I don't even know how I was breathing", he said, adding that Noah's time in hospital changed his mindset and priorities.
"I didn't anticipate returning to recording or performing and I was fine with that", he told Press Association.