Wales were without injured Real Madrid forward Gareth Bale, although he watched from the stands and was honoured on the pitch at half-time for becoming his country's record scorer last March when he overtook Ian Rush's tally of 28 goals.
He has transformed a team that disappointed so much in Russian Federation, into a side that is playing with a new found sense of energy, dominating the ball, passing it with speed and being ruthlessly clinical in front of goal, as proven against Croatia and Wales.
Alcacer was celebrating again in the 29th minute, capitalising on more chaotic defending to beat Hennessey with a sweetly struck low volley, although Ethan Ampadu's looping header hit the outside of David de Gea's post in a rare Wales attack.
The ex-Barcelona coach orchestrated a fine performance which included goals from the in-form Paco Alcacer and Marc Barta as well as a positive display from Alvaro Morata and a heroic clearance from debutant Jonny to prevent a certain Wales goal.
"He who takes advantage of his opportunity and does well in training will have minutes", said Luis Enrique, cryptically.
"It is very unlikely at this point", Giggs told Sky Sports about Bale's availability after the Spain defeat. Alcacer, meanwhile, pressed his case to remain in the squad after a deserved recall.
Giggs deployed a back three, with Ashley Williams captaining the side, but the experienced centre-back struggled to assert his authority. "We'll miss him, we hope he's available for as many games as possible", the Stoke City defender explained.
So, Wales v Spain!
"It's a notable absence for Wales but it doesn't change our concept of the game".