With Mohamed Salah, Pedro Chirivella, Georginio Wijnaldum, Sadio Mane and Marko Grujic sitting out it was an inexperienced Liverpool side that took to the field at Bank of America Stadium in Charlotte, North Carolina.
A Virgil van Dijk had given Liverpool a deserved half-time lead but they fell to a 3-1 defeat against the German side.
Loris Karius (played entire match) - 5: nearly a "Karius calamity" in just the third minute when he played the ball straight out to a Dortmund striker, toughest save he had to make in the first half was from a van Dijk back pass, held one sharp low cross late in first half - though it nearly bobbled out, could not be blamed for the penalty miss or Pulisic's second but palmed Pulisic's shot straight to Bruun Larsen for the third.
Just three minutes later, a super cross saw Virgil Van Dijk soaring with his powerful header finding the net.
It seems Matip is now faced with yet another injury concern, which is sure to come as a blow to Klopp as he continues to gear his Reds side up for the upcoming season.
Both managers made wholesale changes at the start of the second half as they looked to freshen things up.
Later, the 19-year-old followed up with a spectacular goal in the 89th minute to put Dortmund one goal ahead.
The midfielder played 45 minutes here, displaying some nice touches in attacking areas, and is targeting a place against West Ham on the opening day.
Matip's defensive partner Van Dijk opened the scoring in the 25th minute, though.
The former Chelsea man should have had an assist before Dortmund drew level, as he neatly played in Sheyi Ojo for a one-on-one opportunity but the latter's shot was diverted onto the crossbar by goalkeeper Marwin Hitz.
The third, scored by Jack Bruun Larsen, was different.
Rafael Camacho took a short corner to Robertson and he delivered a flawless left-wing cross, allowing Van Dijk to rise unmarked and thump home a powerful header from eight yards out.
Deep into stoppage time, the USA worldwide beat his defender in the box and Loris Karius parried his shot into the path of Jacob Bruun Larsen, who finished into an empty net.