Additional sources have corroborated that Guilfoyle's departure from the network signals that she will soon join her beau on Trump's campaign trail.
Mediaite confirmed that Guilfoyle will not be appearing on The Five on Friday to say farewell.
Guilfoyle will likely take a job at America First Policies, a pro-Trump non-profit, which has worked to recruit her, according to a source who spoke with CNN.
IJR reached out to Fox News for comment but has not received a response.
Amid rumors that Guilfoyle would replace former White House press secretary Sean Spicer last year, she signed a multi-year contract with the network.
Trump Jr. and his wife Vanessa Haydon are recently divorced.
She has recently become a fixture in the gossip rags thanks to her relationship with Donald Trump Jr. By May, the 40-year-old was reportedly dating 49-year-old Fox News co-host Kimberly Guilfoyle. "It doesn't get prettier than this", Trump Jr. said, alongside pictures of Guilfoyle.