It's his first final appearance at a Grand Slam since losing the 2016 US Open championship match to Stan Wawrinka. More importantly, he has the big serve on this fast Wimbledon court to turn the match into a marathon.
The 2018 final is Anderson's second career grand slam final after making it to the US Open final previous year before losing in straight sets to Rafael Nadal.
Anderson is the first South African to make a Wimbledon final since 1921.
The announcement of the curtailment of play was greeted with understandable disappointment by the crowd, the vast majority of whom had stayed as a contest more than worthy of a Wimbledon final played out in front of them.
Isner had previously come out victorious in the longest match in history in 2010 at Wimbledon against Nicolas Mahut, which lasted 11 hours and five minutes over three days.
It was the longest match in the history of Centre Court in Wimbledon.
Djokovic, the Wimbledon champion in 2011, 2014 and 2015, will be bidding for a 13th Grand Slam title when he faces Anderson on Sunday.
You will be able to watch the match live on Seven and can follow all the action on the Wide World of Sports live blog. Even though he didn't convert his first match point at 8-7, his efforts in chasing a Nadal drop shot did not go unnoticed.
That semi-final only finished just before 8pm making it impossible for Nadal and Djokovic to finish before the 11pm curfew. I got Novak to win another major, to be only one behind Pete Sampras in Grand Slam career titles.
Novak Djokovic returns Kevin Anderson's serve. Getty Images
"I need to reset as much as possible", Anderson said.
"Right now I feel bad", the 33-year-old Isner said, noting he developed a foot blister at some point in the match.
Djokovic and Nadal went deep into a fifth set as they slogged it out for over five and a half hours for a place in the final.
That match victor, Kevin Anderson, will be seeking his first major crown on Sunday, while Djokovic-playing in his 22nd Grand Slam final-is seeking his 13th. He is the man responsible for Roger Federer's exit in the quarter-final, after coming back from two sets down to beat the defending champion.
"Until the last shot I didn't know if I would win. It's hard to come back after injuries for a long time and have these kind of results, so I am proud of myself".
He stands at 0-5 with Nadal and 1-5 against Djokovic. "He's definitely playing the tennis of his life", Djokovic said.
Ever so slowly, having looked as if he might be swept away, Nadal worked his way back into the argument, and two sublime drop-shots - one sliced from the baseline, the second from short range - helped him to set-point in the tie-break, but he lost control of a backhand and they changed ends at 6-all.
No better man than John Isner to speak to the no tiebreak rule in the 5th set.
He had break points in the 15th, 21st and 35th games of the decider before taking victory when a tired Isner, who had needed treatment for blisters on his right hand, hit long.