Americans in London have been warned to "keep a low profile" during the trip, while a crowd-funded "Trump Baby" blimp has been cleared for take-off on Friday morning outside Parliament House.
The largest demonstration is expected in central London on Friday where a giant "Trump baby" balloon will fly close to Parliament after being given the go-ahead by London mayor Sadiq Khan. "I like Boris Johnson, I've always liked him", said Mr Trump.
"We've had a lot of questions about respect", she told Sky News. "And I've spent the last eight months going all around the country, meeting people and getting their point of view of all kinds of people whether it's politicians or people working in factories.I don't feel that at all".
"Our trade and investment relationship is unrivaled - we are the largest investors in each other's economies and every day a million British people go to work for US companies in the United Kingdom and a million Americans go to work for United Kingdom companies in the US", May said.
Despite the welcome from May, many Britons are opposed to Trump's visit.
"This week we have an opportunity to deepen this unique trading relationship and begin discussions about how we will forge a strengthened, ambitious and future-proof trade partnership". "The people voted to break it up so I would imagine that's what they would do, but maybe they're taking a different route - I don't know if that is what they voted for".
MORE than 60,000 people are expected to protest against Donald Trump in London tomorrow.
The US President and the First Lady will land at Stansted Airport, Essex, to start his visit to London and the south of England. We are living in very volatile times and so I hope nothing gets out of hand and I hope people can act civilly.
A campaign is also underway to get "American Idiot", a 2004 song by the U.S. punk rock band Green Day, to the top of the UK Singles Chart.
A small demonstration is expected to take place near Blenheim Palace in Oxfordshire on Thursday, the venue for Trump's black-tie dinner with Prime Minister Theresa May.
Nearly all of Trump's activities will be outside the city: He'll meet the Queen at Windsor Castle, not Buckingham Palace.
The first couple departed Tuesday for a trip to Europe, where the president is expected to visit the United Kingdom, attend the North Atlantic Treaty Organisation summit in Brussels, and meet with Russian President Vladimir Putin in Helsinki.
Along with trade and security links, Downing Street said key areas to be discussed between the two leaders included Russia, Brexit and the Middle East.
May welcomed the summit and said it could help address "malign activity" by Russian Federation.