The Egyptians were handed a sucker punch a minute after the restart as captain Ahmed Fathi guided the ball into his own net to put the home nation 1-0 up.
Wonder kid Cherrychev added a second for the host on the night, his personal third in the tournament before Dzyuba ended any Egyptian hope of a revival.
Mohamed Salah has been praised for his strength of character after making a comeback from injury against Russian Federation despite struggling for fitness.
One Russia fan even attended the game with Ramos's name and number on the back of a Real shirt. Russia, who is expected to be boosted by at least 60,000 fans in the arena, smashed Saudi Arabia 5-0 in the opener. But that will be a tall order.
The tournament hosts came away with a 3-1 win in St Petersburg.
It was hardly a fitting comeback for a player who gained global stardom on the strength of a single brilliant season with Liverpool, whom he joined last summer from Roma, and a player who enjoys the kind of popularity no athlete has ever enjoyed in Egypt.
Uruguay's win will also seal Egypt's fate in the tournament and will send them crashing out.
Egypt face Saudi Arabia, by far the weakest team in the competition, on June 25 and will hope to have Mo Salah fully fit by then.
"They are a completely different team".
Former England and Newcastle striker Alan Shearer said he was pleased to see Salah back on the pitch and scoring despite not being fully fit.
Since making his national-team debut in 2011 he's gone on to feature in no fewer than 57 global outings, registering 33 goals - most notably converting the penalty against the Republic of the Congo to book their finals passage - and creating a further 18 for his teammates. We thought the priority was to help him to make sure he was 100 per cent recovered. You can't be distracted when you're playing at the World Cup. "We respect each other and the relationship is best". We lost the match in this period, though the first half was excellent.
The defeat stunned Egypt, a soccer insane nation of some 100 million people whose hopes have been pinned on Salah delivering the desired result. You find out in 180 minutes very quickly which direction things are going to go.