United, who begin their season at home to Leicester City, were the only team to claim three points at the Etihad against Guardiola's champions last season, with Paul Pogba inspiring the visitors to a 3-2 victory in April having trailed 2-0 at half-time.
Nuno Espirito Santo's men won the Championship title at a canter this past season, dominating for most of the campaign and nearly notching up a century of points along the way.
Everton are the opposition at Goodison Park in the first fixture of 2019 on New Year's Day, while Puel's side will also face a testing end to the campaign.
Oh yes, and Mikel Arteta will be on the touchline at the Emirates Stadium at the start of the new season after all...
But when are the 10 biggest fixtures of the season taking place?
This is first time a club has been allowed to play home games at two venues in the same season.
The Blues face a trip to Huddersfield as they look to regain their title, while Spurs will be travelling to Rafa Benitez's Newcastle to open their account.
The other first day fixtures see Southampton host Burnley and Watford take on Brighton at Vicarage Road.
It's going to be a tasty start to the season.