However, it has been less effective with some common epithelial cancers, or cancers that start in the lining of organs, that have lower levels of mutations, such as stomach, esophageal, ovarian, and breast cancers.
That means thousands of women can be safely spared the toxic effects of chemotherapy, says William J. Irvin Jr. the Virginia medical director for medical oncology, and director of clinical research for Bon Secours Virginia Health System and Bon Secours Cancer Institute.
The combo treatment of the two drugs, Pembrolizumab and Decitabine, is given four weeks before chemotherapy begins.
A biopsy would be done before and after that combo treatment.
The two most recent studies it is funding look at tomosynthesis - a newer breast imaging technique - versus standard-of-care 3D mammograms, and research on whether weight loss impacts breast cancer treatment and outcomes.
"I came to realize that I was going to die, and that's where my mind was", the 52-year old from Florida told CBS News. If it is time, you should also schedule an annual clinical breast exam and mammogram, which are key to early detection.
In 2008, a routine mammogram detected early stage breast cancer.
"I'm talking to patients of mine about it today".
The team based at the Leiden University Medical Centre in The Netherlands analysed the anonymised records of 236,015 women who'd been diagnosed with breast cancer before it had spread.
Rosenberg believes Perkins' cells are still working to keep her cancer free. Oncotype DX has been available overseas for almost a decade. It was funded by the National Cancer Institute, some foundations and proceeds from the USA breast cancer postage stamp.
He added that it was important that the federal government funded the study because the pharmaceutical industry has little interest in sponsoring trials that result in a reduction of treatment.
"At lot of works needs to be done, but the potential exists for a paradigm shift in cancer therapy - a unique drug for every cancer patient - it is very different to any other kind of treatment", he said.
Other experts said the results confirm what many patients and doctors are already doing.
In a paper published in December, Kurian and Katz reported that chemotherapy use was plunging among patients with early-stage breast cancer.
Judy Perkins, an engineer, was 49 when she was chosen for the radically new method after the failure of chemotherapy in controlling the tumor which is slowly growing towards her liver and other areas. Perkins said she "cornered her with a beer" and said she wanted to enroll.
Until now, most of those intermediate- risk women would have been recommended for chemotherapy.