"This indictment brings the defendant another step closer to accountability for the crimes of violence with which he is now charged", Vance writes in a statement.
Actresses from Angelina Jolie to Uma Thurman have come forward with stories of their own, and Hollywood heavyweights have been donating their earnings from the Weinstein Company to charities that help sexual assault survivors.
"After being unfairly denied access to critical information about this case that was needed to defend him before the Grand Jury, Mr. Weinstein's attorneys decided that there was not sufficient time to properly prepare Mr. Weinstein", said the statement released to media outlets.
There are also almost a dozen lawsuits filed in the courts against Weinstein from some of the 80 women who have gone public with allegations of sexual assault and more by the once powerful producer.
The 66-year-old was initially charged last week in what was hailed a landmark for the #MeToo movement, almost eight months after his career imploded in a blaze of accusations of misconduct. "Mr. Weinstein has further confirmed that there were never any acts of retaliation against any women for refusing his advances".
Prosecutors haven't identified the second accuser, who told investigators Weinstein confined her in a hotel room and raped her.
While Weinstein's reps and attorneys did not respond to request for comment from Deadline on today's indictment, they can't be deaf to the unflattering shout out Vance just gave them.
Weinstein, 66, had declined to testify in front of the grand jury. Add to that, nudges and winks of " unfair political pressure being placed on Cy Vance to secure a conviction of Mr. Weinstein", and you have a defense strategy in the offering.
The twice-married father of five is indicted with rape in the first and third degrees, stemming from an attack on a woman in 2013, and a criminal sex act against another woman in 2004.
"We remind everyone that an indictment is merely a formal accusation", he said.
Police set up a sting in which the woman recorded herself confronting Weinstein and him apologising for his conduct.
The grand jury indictment spares the prosecution the step of having to go before a judge to demonstrate there is enough evidence to bring Weinstein to trial.
Governor Andrew Cuomo, also a Democrat, ordered the state attorney general to investigate how Vance handled that matter.