He was lifted for Robert Gsellman after allowing the first five Toronto batters to reach safely in the fifth.
His batterymate wasn't bad with the bat, either.
The Toronto Blue Jays recalled reliever Danny Barnes from triple-A Buffalo on Wednesday and optioned reliever Deck McGuire to the Bisons. The Blue Jays now sit in third place in the AL East with a 21-20 record.
Juan Lagares had four hits and three RBIs to help NY improve to 12-0 at home against Toronto - the longest such streak in interleague history, according to the Elias Sports Bureau.
The Mets tacked on three more runs in the fifth, started by singles from Mesoraco and Adrian Gonzalez. He was a fan favorite during his time in Flushing and the Mets will likely have something nice planned for him.
"It was very cool".
This performance comes at a welcome time for Syndergaard, as he got his first win in six starts for the Mets.
Jaime Garcia allowed two runs - one earned - in five innings and did not factor into the decision against the Mariners on Wednesday.
Roberto Osuna: Administrative leave extended
"I felt great in the first inning".
"I think it was more just how I was feeling in my bullpen before the game, what I felt I could execute with throwing strikes", he said, when asked if throwing the four-seamer was in response to the weather. "Once it clicks, I'll be looking forward to that".
Justin Smoak put the Jays ahead 1-0 on a solo blast to right in the first inning. The Mets have scored three runs or fewer 16 times in the last 25 games, including each of the last four.
Toronto drafted Syndergaard 38th overall in 2010 and shipped him to the Mets in a package for then-reigning NL Cy Young Award victor R.A. Dickey in December 2012. The Blue Jays had averaged 2.8 runs over its past 11 games, batting.211 with a.630 OPS while going 3-8. Lagares then drove in another run with his third hit of the game, an infield single, to give the Mets a 9-2 lead. Eduard Pinto of the Dunedin Blue Jays is Florida State League (single-A advanced) player of the week (.476, 10-21, 2-2B, HR, 3 RBI) while Lansing Lugnuts' Kevin Smith is Midwest League (single-A) player of the week (.500, 12-24, 5-2B, 1-3B, 4 RBI). I'm still confident that'll change, because we're too good down there.
Curtis Granderson received a warm hand in his first game at Citi Field since the Mets traded him last August.
The New York Mets trounced the Toronto Blue Jays last night in interleague play, winning by 10 runs, and their starting pitcher on the night Noah Syndergaard got one of the highlights of the season so far with a pitch that stunned the baseball world. He is tied for the team record with 21 leadoff homers. The club showed a tribute video just before the game and Granderson smiled as he pointed at a live camera while getting loose on the field. Martin became the seventh Toronto shortstop this season.
"He was outstanding on a tough day to play, whether you're a pitcher or anybody else", said Jays manager John Gibbons. "Wish the circumstances were a little bit different".
NOTES: Cespedes sat out after an MRI revealed a mild right hip flexor strain. Cespedes has been dealing with the nagging injury for more than a week, though he's described it as discomfort in his quadriceps.