"In the past year and a half Russian Federation has fully restored Syria's air defence system and continues to further upgrade it", Rudskoi said.
Early on Saturday, US President Donald Trump announced the military action in Syria in response to the alleged chemical weapons attack in the city of Duma in the Damascus suburb of Eastern Ghouta.
Three sites were hit in Syria overnight - two in Damascus and one in Homs - all of which were linked to the storage, or alleged testing of chemical weapons.
Russian Federation on Saturday called for an emergency meeting of the United Nations Security Council as Moscow said it would consider supplying S-300 missile systems to Syria following US -led strikes.
"First the "Arab spring" tested the Syrian people, then Islamic State, now smart American rockets".
In remarks made on her official social media account, Foreign Ministry spokeswoman Maria Zaharova said: "Those behind it lay claim to moral leadership in this world and declare their exclusiveness and uniqueness".
Antov added that it was not acceptable to insult Russia's president: "Insulting the President of Russian Federation is unacceptable and inadmissible".
"You have to be quite abnormal to attack Syria's capital just at the moment when it had a chance for a peaceful future".
"Not one of the cruise missiles released by the USA and its allies entered the zone of responsibility of Russian air defences protecting facilities in Tartus and Hmeimim", the ministry said in a statement carried by the RIA Novosti state news agency, referring to the locations of Russia's naval facility in Tartus and its Hmeimim air base.
"The worst fears were justified: our warnings were ignored, a script prepared in advance is being put into practice, and again we are threatened".
Moscow also said it was calling an emergency session of the United Nations Security Council, where it is a permanent member, to discuss the "aggressive actions" of the U.S. and its allies.
Announcing the strikes, US President Donald Trump criticised both Russian Federation and Iran, which have backed Assad's government.
'We can not allow the use of chemical weapons to become normalised - within Syria, on the streets of the United Kingdom, or anywhere else in our world.