Batsmen Usman Salahuddin and Saad Ali could also make their Test debuts as Pakistan aim to rebuild their Test team after the retirements of Misbah-ul-Haq and Younis Khan.
Fast bowler Wahab Riaz, 32, is omitted, with leg-spinner Yasir Shah injured.
"Yasir's absence is a big loss for us", chief selector Inzamam-ul-Haq said Sunday.
Batsmen Usman Salahuddin and Saad Ali, and all-rounder Faheem Ashraf are the other three uncapped members of the squad.
Yasir has taken 164 wickets in 28 Test matches since making his Test debut in 2014 and has been instrumental in Pakistan's success - especially in the UAE. "If we look at his numbers for the last two years, he has more wickets than any other bowler for Pakistan". Shadab Khan, who has been a regular fixture in the limited-overs team, has been drafted in the squad. He was our strike bowler, all the games we've won he played a big part in.
Haris Sohail, who retains his place after he made his debut in the home series loss against Sri Lanka previous year, may also find himself in a crucial all-around role with his part-time spin.
Despite it being one of his worse seasons in the domestic circuit, Fawad was the sixth highest run-scorer of the tournament with 570 runs at an average just above 40.
Haq said selectors had tried strengthen the side's batting, which was weakened after the retirement a year ago of Misbah-ul-Haq and Younis Khan.
Fawad Alam, son of Pakistan's famous first-class cricketer Tariq Alam, made an early start to his first-class career at the young age of 17, he also played in the under 19 world cup for Pakistan.
A single Test against Ireland in Dublin begins on 11 May, before matches against England at Lord's and Headingley.