Givenchy first lent the actress clothes for the 1954 film Sabrina, after which she became his muse for 40 years.
"His enduring influence and his approach to style reverberates to this day".
The aristocrat, who founded the house of Givenchy in 1952, rose to fame during that decade, when he also became a cinematic legend due to his collaborations with Hepburn.
In 1981, The House of Givenchy was split into a perfume line, which went to French champagne house Veuve Clicquot, and a fashion branch that was acquired by is European multinational luxury goods conglomerate LVMH in 1989.
It was announced yesterday that French fashion designer Count Hubert James Marcel Taffin de Givenchy passed away on Saturday 10 March at the age of 91.
Lifetime Achievement Award obtained, Givenchy packed up his couturier tools in 1995, but never walked away from fashion. The sleeveless black evening gown she wore in the movie, complete with rows of pearls, elbow-length gloves and oversized shades, would end up becoming Givenchy's most famous look.
Grace Kelly and Jackie Kennedy were other famous clients of Givenchy, a name synonymous with understated elegance.
Born into an aristocratic family in the provincial city of Beauvais on February 21, 1927, Givenchy struck out for Paris in his late teens.
"France loses a master, the Master of elegance, of creation, of invention", the statement said, sharing the condolences of President Emmanuel Macron and his wife, Brigitte, to Givenchy's companion and friends.
Givenchy is now headed up by Clare Waight Keller, who is the label's first ever female artistic director. In 1961 Hepburn and Givenchy created a moment in cinema that thousands of women with aspirations of unprecedented levels of glamour still hold dear to their hearts today.
He is survived by his long-time partner and former designer Philippe Venet.