Mourinho, who wore a Munich pin badge in the news conference previewing that game, said: "I was telling before MUTV that this is something that is part of my life, or part of my football culture, before I become Manchester United manager".
"Even before I became Manchester United manager it was part of my life as a sportsman".
"Because it was such a tragedy that it stayed over these last 60 years". "If we believe they are watching the match I think it's one more reason for a happy day and for a good performance and a manifestation of United colours".
"At the same time, it is a crucial point also in Manchester United's history - the reaction, the strength, the union after that situation".
"So, we pay respect to the victims and their families, and they will always be in our memories".
Supporters gathered underneath the Munich plaque outside the ground before kick-off to take part in their annual event to carry out readings, prayers and a rendition of "The Flowers of Manchester".
Both sets of fans received a commemorative pack containing a limited-edition book detailing the story of the disaster, a matchday programme and a letter from the club's executive vice-chairman Ed Woodward.
Juan Mata dedicates win over Huddersfield town to Munich air crash victims
This is comfortably United's best league campaign since Alex Ferguson retired as a champion in 2013, yet Pep Guardiola's swashbuckling side boast an eye-watering 15-point cushion at the summit.
The result ensured United will end matchweek 26 in second spot, but rivals Manchester City still lead the way by 13 points.
However, he survived and rebuilt the side leading it 10 years on with an epic European Cup victory.
Mourinho anticipates the occasion will elevate the players' performance as they attempt to win the game in a bid to bring happiness to all of those who lost someone in the crash. He felt that moment as a click for the improvement of the team.
"But I think we did what we had to which was press up, play in the other half, recover the ball as soon as possible and play with intensity".