Halep, the top seed for the women, made it through qualifier Destanee Aiava in straight sets, 7-6 (5), 6-1.
"We've been told that we have a special guest, who wants to ask a couple of questions", announced retired tennis champ John McEnroe. "Give it up for Will Ferrell".
"I've practised with him [Struff], and played against him in doubles and singles", said Federer, in an on-court interview with former World No. 1 Jim Courier.
What he found tough on Tuesday was to rally with Will Ferrell in the post-match on-court interview.
Federer laughed, replying: "Maybe, maybe not". When they see a mini chance to get on the offensive, they just go for it.
Ferrell: "Not if they're fast enough".
"Probably a vampire." Ferrell said.
The Anchorman star also managed to have a dig at Aussies as he asked whether a rumour Federer only ate "wombat" meat while competing in Melbourne, which he described as "delicious" and "the national food of Australia".
"That's why I see things more relaxed, you know, at a later stage of my career". They are an fantastic crowd, but does it get annoying when they just scream: 'c'mon Roger. "C'mon Roger!' over and over again?"
Federer: "They remind me of my own name". The Swiss produced a majestic display to show why he is favourite to win his sixth Australian Open and 20th Grand Slam title at the age of 36.