Ant and Lisa have been together for over 20 years and married for 11.
The couple met at a roadshow in Newcastle in the mid-1990s while Lisa was an aspiring pop star in a group called Deuce, who enjoyed a couple of chat hits before breaking up.
It continued: "Ant asks for privacy at this hard time, for both himself, Lisa and their immediate families".
Ant is said to be keen to maintain an "amicable" relationship with the Strictly Come Dancing make-up artist, who was previously accused of not "standing by" her husband by angry fans.
McPartlin entered rehab last summer and a source told the newspaper that his marriage had "effectively been struggling for eight months".
However, the insider added that the Geordie TV presenter hopes to make things "as easy as possible" for Lisa, adding that he will "look after her in the settlement".
Lisa used to be a singer in 90s band Deuce, while Ant was in PJ & Duncan with his best man December.
Ant, 42, had entered into rehab earlier past year to try and battle his addiction to painkillers.
Showing her support for her son during the hard period, Ant's mum Christine brought along her pooch, and chatted to her son as they walked along.
"No further statement will be made".
Lisa appeared to hint that things had taken a turn for the worst when she posted a picture which labelled 2017 as a rubbish year.
It wasn't until 12 years later that the smitten couple finally Wednesday at a church in Taplow, Buckinghamshire in front of 150 friends and family.
The star returned to television screens in November after a stint in rehab for prescription drug and alcohol problems.
"I've put Lisa through hell with mood swings and depression and how it affects you", he said at the time. "I'm very sorry about the effect it has on partners".
After dating for more than a decade, Ant proposed to her during a romantic sun-drenched holiday in Dubai on April 26, 2005. 'If we're blessed with children, then we'd be over the moon!'