So dominant was Djokovic since the loss to Nadal at the 2013 US Open that he outclassed the Spaniard 11 times in the next 13 meetings.
In the absence of Serena Williams and Victoria Azarenka, only two former champions are in the women's draw.
To predict a victor of either of the singles titles is hard.
Here, we assess the chances of the favourites, outsiders and dark horses following the draw for the first slam of 2018...
Players have complained that the tour is too hectic but they are forced to play in maximum tournaments to keep their ranking where it is.
AUCKLAND: Top-seeded and defending champion Jack Sock bowed out of the ATP Tour's ASB Classic in its second round Wednesday, beaten 6-3, 6-3 by unseeded German Peter Gojowczyk on a bad day for American players.
Naomi Broady battled through to the second round of qualifying at the Australian Open but there were defeats for Cameron Norrie and Katie Boulter.
Cilic, last year's losing Wimbledon finalist against Roger Federer, heads into his final practice days for the Australian Open content with his form. In the top half of the draw, Rafael Nadal's first serious threat ought to come in the shape of John Isner in the fourth round. Despite being very tempted to predict that Alexander Zverev will make his major grand slam breakthrough in style by going all the way, I think he may just fall short.
A knee injury which has prevented Nadal from playing competitively since losing to David Goffin at the ATP Finals in November has restricted the 16-time major champion to just a pair of exhibition contests in Melbourne - a far cry from his run to the quarter-finals at the Brisbane International past year.
To choose a potential "dark horse" for the title is slightly easier as both draws are wide open.
The waiting is nearly over for tennis fans.
Grigor Dimitrov has always been touted as the player most likely to break the "Big Four" stranglehold. As for the men's draw I am going to give Juan Martin del Potro the "dark horse" label. He had an exceptional 2017, winning seven titles, including two Slams - the Australian Open and Wimbledon. Wins four or five matches at the Hopman Cup against high-level competition. If del Potro is fit, then he could go far in Australia, but until all doubts over his conditioning have been proved wrong, he should be viewed as an outsider for the title. However, her inconsistency in recent months will be her undoing and will be a big miss for a tournament lacking star names.
The final category is the young players to watch. There is even more room on the women's side with the 2016 champion Angelique Kerber back on target and with a new coach, Wim Fissette, after slumping in 2017.
Stan Wawrinka, who won the Australian Open title in 2014, is also set to return after a long injury lay-off, and though he hasn't played any matches yet, he is seeded ninth in the men's draw.