The Dutchman became the world's most expensive defender after completing a January 1 move from Southampton to the Reds, where he has already hit the ground running after scoring the victor in the FA Cup clash against bitter rivals Everton. They famously ended that 49-game unbeaten league run in a fiery United-Arsenal match to end all United-Arsenal matches.
One man who could make the difference for Manchester City is Raheem Sterling. City have looked imperious and even though the mood at Anfield is somewhat tiresome after Philippe Coutinho's sale to Barcelona, expect the Reds to be competitive and threaten City's unbeaten run in the League.
Sadio Mane, Mohamed Salah and Roberto Firmino still combine to form a unsafe attacking trident, and the addition of big-money center back Virgil van Dijk should help Liverpool both in the back and on set pieces, where City could be more vulnerable.
Barton however thinks the win City crave will still prove elusive.
The Egyptian suffered a groin injury, which made him miss his side's last two encounters against Burnley and Everton, but now he is in line to start the Manchester City game on Sunday.
"City have got the League title sewn up, make no mistake about that".
Is Alexis Sanchez on his way to Manchester City? It's worth noting that this game could very well be postponed.
Man City are 5/4 favourites, while the draw is 13/5.
Sturridge has not featured for Liverpool since November and is looking for regular football
Manchester City are without Gabriel Jesus who has damaged his knee and is expected to be out action for a month.
"They would grind out results, grind out results", Quinn said of Arsenal.
Any team willing to press and attack City have found success, and they have found the net.
Their first meeting: City eked out a 1-0 win at Stamford Bridge, with former Chelsea product Kevin De Bruyne netting the game-winner in the second half.
Will the 26-year-old be able to put in another top shift against Manchester City's explosive offensive threat?
The Belgian has been a level above everyone this season and has the PFA Player of the Year award all but in the bag. The amount of goals he has scored from outside the box is just ridiculous.
Liverpool FC, meanwhile, are down in fourth place as they look to try and secure Champions League qualification for the second season running under Jurgen Klopp. Going to any of the top four away from home is hard.
Klopp might note that the one side to hold an 11-man City in the league, Crystal Palace, did so using the 4-3-3.