The Belgium worldwide has been quoted as saying he is ready to sign a new deal at Stamford Bridge.
"With Wes, I don't know for the moment how long he will be out, but he will not make not be in the squad for Chelsea".
"He can continue to make progress", said Puel.
In an intriguing twist of fate, midfielder Adrien Silva is set to make his first start for Leicester - he is the player they signed to replace Chelsea-bound Danny Drinkwater but missed the Federation Internationale de Football Association registration deadline by minutes on transfer deadline day. But, Conte is expected to continue with the 25-year-old player in this match.
Unbeaten in nine but winless in three, Chelsea could use a little boost before taking on more midweek Cup duties (Norwich FA Cup replay next; Arsenal League Cup semifinal second leg to follow a week after). "They lost to Watford, who have won once in a blue moon, and with Chelsea needing a win to consolidate their position in the top four, I fear for the Foxes".
Luis Enrique and Massimiliano Allegri are favourites to replace Antonio Conte
It is important to have a good balance in the team and have a good game time for the players.
The Premier League is back this weekend which would usually fill me with delight after an average weekend of FA Cup betting - but then I took a look at the fixtures.
Paul Merson is predicting that Chelsea will edge to a 2-0 win over Leicester City at Stamford Bridge on Saturday afternoon.
But Puel could always see the player's ability when the pair were together at the Metropole.
Swift improvement is needed if his first-team stars are to take anything from their trip to west London, with Chelsea having scored 10 goals and conceded only one in their last four home matches.
"Eden is a fantastic player but I wouldn't man-mark him. We have great players also and quality in the squad and a great attitude all the time in training sessions on the pitch". However, Puel has pointed to Leicester's highly-competitive clashes against the Premier League big boys as a key reason as to why the Foxes could collect three points this weekend.