Arsene Wenger will sorely miss his defensive mainstay in Nacho Monreal who has been ruled out of the fixture due to injury while midfield engine Aaron Ramsey will also sit as he is also now sidelined.
The last time the Gunners travelled to Selhurst Park in April, they were on the end of a comprehensive 3-0 defeat.
The Gunners have also been in good form, their only defeats in their last eleven league games have come against the two Manchester clubs, but there is a sense that too many points have been dropped in disappointing draws. The six points dropped in those three games would now have them in fourth on 40 points.
Jason Puncheon remains available for selection despite being charged with possession of an offensive weapon and assault while Joel Ward is still struggling with a groin problem.
As far as the team news is concerned, Nacho Monreal started in the central defense with Koscielny against the Reds but he is now suffering from an ankle injury. "Aaron Ramsey should be back at the beginning of January".
Hodgson's side are on an eight-match unbeaten run (W3, D5) - their longest top-flight run since a 12-match stretch in October 1990.
Arsenal travel to Selhurst Park on Thursday night to face a resurgent Crystal Palace. With Wenger's men enduring their worst run away from home since Arsene Wenger took charge over two decades ago, Wilfred Zaha and co will fancy their chances of testing Arsenal's defensive unit. Having only failed to find the net once in their last 14 Premier League apperances, backing both teams to score at 4/7 seems like a logical bet here.