Sgt Embree said: "With that many people on a plane, there are injuries".
"There was no explosion or fire", police said in a release. "A number of people have suffered injuries, some serious enough to require air ambulance services".
A West Wind Aviation plane carrying 22 passengers and three crew members crashed near the Fond-du-Lac, Sask., airport shortly after takeoff early Wednesday night, the RCMP says. RCMP members located the plane less than a kilometre from the airstrip.
Passengers travelling to the United States will be facing long delays one day after 400 flights were cancelled due to the first major snowfall of the season.
There have been no reported fatalities in the crash of a regional airliner in northern Saskatchewan in Canada on Wednesday.
Fond-du-Lac is a remote fly-in community in northern Saskatchewan
"Right now our primary concern remains with the passenger and crew that we're trying to look after right now", said Philipenko.
The West Wind Aviation ATR-42 went down about a km from the Fond-du-Lac airport at around 6:15 pm local time (0015 GMT, 11pm Malaysia time Thursday), the Royal Canadian Mounted Police said.
Transportation Canada will take over the investigation into the cause of the crash.
Fond-du-Lac is a remote fly-in community in northern Saskatchewan.