Robert Lewandowski opened the scoring and Corentin Tolisso struck twice as Bayern Munich fell just short of topping Group B with a 3-1 win over Paris Saint-Germain at the Allianz Arena.
After their shock defeat by Strasbourg in Ligue 1 at the weekend, cracks are starting to show in Unai Emery's side.
At Inter, Mourinho depended upon captain Javier Zanetti in all manner of positions - left-back, right-back, central midfield - and deployed Cristian Chivu, once considered the most promising young central defender in Europe, as a left-back and midfielder. They later teamed up at Real Madrid.
With doubt still surrounding the future of key forward Antoine Griezmann, Tuesday's 1-1 draw at Chelsea could yet signal the end of a wonderful four-year spell for the Spanish club. If Roma fail to win, Atletico could snatch second with victory rather than qualifying for the Europa League. A favourable draw could now put them on the brink of a first quarter-final appearance in ten years.
Last season's beaten finalists Juventus clinched a spot in the knockout round after beating Olympiakos 2-0 in Greece, Juan Cuadrado and Federico Bernardeschi on target for the Serie A champions.
United won Group A after coming from behind to beat plucky CSKA Moscow 2-1 at Old Trafford to reach the knockout rounds for the first time since 2013-14.
File Manchester City manager Pep
It wasn't the superstars - Paul Pogba, Romelu Lukaku, Anthony Martial or Zlatan Ibrahimovic - who proved decisive in these games, but the underrated, consistent, versatile and hard-working squad members who embody everything that successful United teams have been about.
But Mourinho insisted he is not motivated by breaking new ground against City, who have won their last 13 Premier League games going into the derby.
Wenger ruled Lacazette out of Arsenal's meeting with United last weekend due to a groin injury, only for the French striker to play the full 90 minutes and score his side's goal.
Barcelona have not been at their free-flowing best for much of the season so far, but still lead La Liga by five points and eased into the last 16 as Group D winners. Juve won at Olympiakos 2-0 and joined group victor Barcelona, which beat Sporting Lisbon 2-0.
"I think the Arsenal game was obviously a great result and I loved the way they pressed Arsenal".