The first tie ended with Juventus being thrashed 3-0 at the Nou Camp. After years of dominating Serie A, they now sit in third place in Italy's top division, four points out of first place thanks in part to a shocking 3-2 loss at the hands of Sampdoria, a loss that only looks as close as it was thanks to two stoppage-time goals scored by the Old Lady.
A win for the Spanish giants would guarantee them top spot. They're coming off six wins in their last seven in all competitions and can lock down first place in the group with a win.
Barcelona have hardly dropped any points at this stage of the season, just two in La Liga and two in the Champions League all campaign long.
Recently-retired Italian worldwide Chiellini has proven one of the few bright sparks in Juve's uncharacteristically shaky backline this season, with two of Daniele Rugani, Andrea Barzagli and Medhi Benatia now set to be given the nod from the start tonight (Benedikt Howedes could also make his first appearance for the club).
"Now that he has left I have to run up and down the wing, it's not a problem for me".
"They have many talented players, Paulo Dybala probably one of the most important, but Miralem Pjanic, Gonzalo Higuain and Juan Cuadrado can also make a difference".
Ernesto Valverde has a number of injuries in his squad, but none of them are regular first team players so the Spaniard wouldn't be too anxious. Rafinha, Sergi Roberto and Javier Mascherano are all still out.
Catalans welcome back Gerard Pique to the squad following his one match ban.
Andres Iniesta, Sergio Busquets and Ivan Rakitic are front runners for the 3 places in midfield while Luis Suarez, who ended his goalscoring drought with a brace on Saturday, is expected to lead the line alongside Messi and an in-form Paco Alcacer.
Tonight's opponents Juventus have had their troubles in Serie A this season, especially most recently, as they lost 3-2 in shambolic fashion to Sampdoria on the weekend.
In that time, Barcelona have scored 13 goals against Juventus, while conceding 10.
The game will be held at the Allianz Stadium.
Juventus vs Barcelona: How does the group stand?
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