"Congratulations", MacFarlane said after announcing Best Lead Actress nominations, "you five ladies no longer have to pretend to be attracted to Harvey Weinstein".
By this point, several stories attempting to expose Weinstein's casting couch antics had been killed by higher-ups.
MacFarlane claims Barth - who he's worked with on "Family Guy" and the "Ted" films - confided in him in 2011 about Weinstein's attempted advances. and it pissed off Seth so much, he ripped Weinstein at the Oscar noms event. Make no mistake, this came from a place of loathing and anger. An ever-growing number of victims have spoken out about Weinstein's alleged harassment since last week's New York Times exposé; this number includes Ted star Jessica Barth who told the New Yorker that Weinstein invited her to a business meeting at the Beverly Hills Peninsula hotel and demanded a naked massage.
"We discussed the possibility of a separation and I encouraged her to do what was in her heart".
Was Harvey Weinstein's reputation in Hollywood well known long before allegations of sexual harassment and assault emerged?
MacFarlane took some heat on social media after issuing his statement Wednesday, with critics contending the 2013 comment proves he was aware of Weinstein's behavior but - aside from making the televised jab - did nothing else to stop it.
It came hours after actresses Angelina Jolie and Gwyneth Paltrow claimed Weinstein targeted them early in their careers and he faced bombshell claims he raped three women, including Italian actress Asia Argento.
"He stood by me and respected my wishes not to retaliate in any way, "Barth wrote of MacFarlane".
- Jessica Barth (@_jessicabarth_) October 11, 2017 Oh my god, seriously!?
"I respect and applaud my friend Jessica and those sharing their stories for their decision to come forward, and for being champions of the truth", MacFarlane tweeted.
"To everyone bad mouthing Seth, how about applauding him for being one of FEW men in Hollywood speaking out!"