With the Champions League fixtures also set to kick in, this will test the Reds depth of squad and real Premier League criteria.
The pressure is on Ronald Koeman to start to deliver on the season that promised so much, yet so far has flattered to deceive.
Guardiola said: "All we can say is just to convince him to be involved in the way we want to play - not to be (just) like a striker heading the ball in the box and scoring a goal, but to try to make one high press in the right moment to help to win the ball as quickly possible, to attack as quickly as possible and to be involved in the process to play football".
In 2011 Toure scored the victor in City's 1-0 FA Cup final victory over Stoke to end the club's 35-year wait for silverware and has won the league in 2012 and 2014.
He said: "You can imagine going against a Tony Pulis team and playing 90 minutes in those conditions, then you spend three or four hours on the bus". Three days later we have a game, then three days later after Stamford Bridge we have the Champions League.
"So for the managers, there's a lot of wasted energy".
Guardiola, like most managers, made major changes for the midweek cup win over West Brom and is poised to switch back to a first-choice XI for the visit of Crystal Palace in the Premier League on Saturday.
"We knew that before, so it's not a complaint in those terms".
"But he showed his personality because it's not easy for him to play in these type of games but he did it well and that's why we're happy for him to come back".
They are favourites to beat Palace, who are bottom of the league without a point or a goal.
Given Palace's dismal form - they have made the worst ever start to an English top-flight season with five defeats and no goals - it would be little surprise if Aguero reaches Brook's haul on Saturday.
Pep Guardiola recaps his team's convincing 6-0 win over Watford, and how he loves watching good football like any spectator. Mourinho believes the key to United's success has been his forwards playing with a more positive attitude this season.