At least four people have died after a crash involving several vehicles, including a lorry, on the M5 in Gloucestershire.
The motorway is closed in both directions between junctions 16 and 14 while the emergency services work at the scene.
Emergency Services say the road is likely to stay closed for a considerable time.
"Sadly, at least four people have died".
South Western Ambulance Service Trust say a critical care team and a dozen ambulances are the scene of the crash dealing with the wounded.
Images on social media showed a lorry which had gone headfirst into a ditch at the side of the motorway, while other images also showed damage to the central reservation.
Cardiologist Dr Amer Hamed was in a auto travelling "10 to 20 seconds behind" when the crash happened.
The Mirror reported witnesses as saying the accident happened after a lorry travelling on the southbound carriageway smashed through the barrier and ploughed into "several vehicles".
He was one of the first at the scene alongside a passing GP and different doctors to help a harmed lady who was in one of the autos.
Dr Hamed added: "People are helping as much as they can". "One vehicle was completely destroyed, nearly like there was only half a auto left with what looked like somebody trapped inside. We're going to be stuck here for a few hours yet".
They said: "Stuck on M5".
"Several people offered us water and one man came out of his auto to give food".
The lorry that has slammed has hit what M5 workers will know as a well-known historic point, a windsock beside the street.
Highways England said the "early expectation" is that the M5 "will remain closed in both directions late into this evening".