But Leicester couldn't resist a relentless final 15 minutes from Wenger's side, and Giroud's win was a cruel blow to a side that had offered so much to an exhilarating 90 minutes.
Nigeria midfielder Wilfred Ndidi started for Leicester City as Arsenal came back from 2-1 down to beat the Foxes 4-3 in a seven-goal thriller in the opening game of the English Premier League on Friday night, Completesportsnigeria.com reports.
The north London side's lead lasted just over two minutes as Shinji Okazaki headed home from close range after some poor defensive errors from the Arsenal goalkeeper and defender.
The pressure eventually told as, in the space of two minutes late on, Ramsey controlled Granit Xhaka's pass and smartly tucked past Schmeichel, before fellow sub Giroud headed in off the bar from a corner to earn maximum points for his side.
Vardy then slid the visitors ahead from Marc Albrighton's cross, before Danny Welbeck drew Arsenal level at the end of a pulsating opening half. But I don't want him to go and in the end he made a decision to stay.
Ever since France striker Alexandre Lacazette joined in July for a club-record 60 million euros ($68 million), the future of compatriot Giroud has been in doubt.
"Not only as a player, he is a fantastic player, but as well in the group". Manager Arsene Wenger this week revealed that he gave the player the option of leaving, but that he chose to fight for his place.
"You come away from home, score three goals and are almost there and then concede two.bitterly disappointed", he said.
"I think we have all seen the amusing business of the transfer window and we never know what is round the corner. We were quite good past year on corners and overall I believe that with a bit of work we can get that out of the system".
"I'm always looking for the positives, we came to the Emirates and the players executed the game plan".