'The United States, everywhere, all over the world, actively interferes with electoral campaigns of other countries, ' Putin said.
On the alleged connections with Donald Trump's people and accusations of interference with United States elections had been "selected by someone as a line of attack against the current [US] president", Putin told the NBC host.
US intelligence agencies have concluded that Russian Federation meddled in the presidential election.
He also had an equally feisty reaction when asked if he had a dossier of information on Trump that he was using to blackmail the president.
Kelly said that Putin hinted that the Central Intelligence Agency could have even been behind the hacking, noting that many people were once certain that Moscow was behind the assassination of former U.S. President John F. Kennedy.
Putin said many chief executives of major USA companies visit Russian Federation and "do you think we are gathering dirt on all of them now?"
"They have been misled", Putin responded when Kelly said that American intelligence agencies had concluded that Russian Federation interfered in the campaign with the goal of electing Trump.
"There was a time when he used to come to Moscow", he said. But you know, I never met with him. During the presidential transition, lots of information from an unknown source was published, information that led Americans to believe that Russian Federation had implicating information on President Trump.
Then why did the USA intelligence services say it was the Russians?
But most of the activity on social media centered around how Putin owned Kelly for the entire interview.
"They have been misled", Putin told NBC, in an interview NBC said was recorded on Friday.
"This is just some kind of nonsense", Putin said in response to a question about Kislyak meeting Trump campaign officials.
"[Putin] talked openly about his family, and it was off the record so I won't get into it, but he talked lovingly about his family", the NBC host said. "That's the extent of my acquaintance with Flynn". Putin rebuffed the accusation.
Comey probably will be asked about conversations he had with Trump concerning Russian election meddling and the FBI investigation into former national security adviser Michael Flynn. "I didn't even really talk to him", Putin said. "There is a theory that Kennedy's assassination was arranged by US intelligence services", the Russian president added.
"This isn't for us to get into, these are your domestic political squabbles. He used to be in the security services.'" "That's it", Putin said, speaking through a translator. "Your lives must be boring". While promoting the interview, Kelly teased that Putin also suggested the C.I.A. itself was behind the hacks, "likening this one to that involving the J.F.K. assassination and the conspiracy theories surrounding that".
In the preview, the Kremlin chief was asked about the nature of his relationship with the retired US Army general who is the subject of several investigations at home.
Next Sunday, Megyn Kelly is set to interview sportscaster and television personality, Erin Andrews. "And such situations do occur in the history of the United States".