Serbian tennis player Novak Djokovic celebrates his victory over Slovak tennis player Martin Klizan.
After his confounding exit from the Australian Open just over a month ago, Kyrgios was a man on a mission in Acapulco, powering to the straight sets win.
Aiming for his first hard-court title since the 2014 Doha, Nadal will take on third-seeded Marin Cilic for a spot in the final.
The tournament victor in 2005 and 2013, Nadal needed nearly two hours to finish off Nishioka.
Also on Monday, the 20-year-old Croatian Borna Córic, breezed past Mexican Lucas Gomez by 6-1, 6-1 in just 57 minutes to move on to the next round where he will play against the victor of the match between Ukrainian Alexadr Dolgopolov and Marin Cilic. Querrey, a semifinalist previous year, will face a victor of the match between defending champion Dominic Thiem of Austria and Adrian Mannarino of France.
Sixth-seeded Nick Kyrgios, of Australia, also advanced, rebounding to top Israel's Dudi Sela 3-6 6-3 6-3.
No 1 seed Novak Djokovic reached the second round with victory over Martin Klizan
Owing to his preparations for the Wimbledon, Ace Tennis star Rafael Nadal has entered the semifinals of the Mexican Open after beating Japan's Yoshihito Nishioka 7-6 (2), 6-3. Nishioka had an early lead in the second set as well but this time Rafa broke back immediately to limit the damage, and he took control in the remaining games, breaking again in games 5 and 9 to wrap up a hard-fought win for the place in the last 4. Mladenovic beat Belgium's Kirsten Flipkens 6-4, 6-3.
Argentina's Juan Martin del Potro barely got past American qualifier Frances Tiafoe 6-4 3-6 7-6 (1).
The sixth-seeded Canadian is starting off against someone who isn't now in the rankings, Ajla Tomljanovic.
None of the other seeds in action dropped a set.
In fact, there is not a major titlist in her draw, with the top seed being Australian Open semifinalist Mirjana Lucic-Baroni.
American Christina McHale beat Puerto Rico's Monica Puig 6-2, 6-2.